Spectroscopie d’absorption des rayons X du calcium à l’échelle du micron sur l’os cortical

What are the assets of synchrotron microtomography SR-μCT here?

++ Non-invasive, real-time analysis

SR-μCT allows direct, non-invasive monitoring of structural changes in pellets, in particular the formation of cracks in polymeric coatings, without complex sample preparation. This reduces the risk of creating artefacts and provides a more accurate analysis of the internal dynamics of solid pharmaceutical dosage forms.

++ Optimisation of formulations

By better understanding the underlying mechanisms of drug release, such as osmosis and mechanical stress, manufacturers can optimise the design of coated tablets, reducing the amount of trial and error usually required in the development of new formulations.

++ Improved modelling and prediction

The data obtained from SR-μCT is also used to develop models, making it easier to predict drug release behaviour as a function of the composition of coatings and the internal structure of tablets, lozenges or pills.